debilitate
UK: dɪˈbɪlɪteɪt | US: dɪˈbɪlɪteɪt
vt. to weaken or make someone or something physically or mentally feeble
vt. to impair the strength or vitality of
Debilitate traces back to Latin debilitare ("to weaken"), combining de- (indicating reversal) and -bilitare (from habilis, meaning "able"). The word originally conveyed the idea of "taking away ability" and evolved into its modern sense of causing physical or mental weakness. The morpheme bilit is a reduced form tied to strength, appearing in words like "ability" and "rehabilitate."
The prolonged illness debilitated his immune system.
Economic sanctions can debilitate a nation's infrastructure.
Sleep deprivation debilitates cognitive function over time.
The harsh climate debilitated the explorers' endurance.
Chronic stress may debilitate both mental and physical health.